Dr. Bolton a physician-scientist with a background in medical oncology and genetic epidemiology. The focus of her research is regarding the interplay between inherited genetic variation, environmental factors, and acquired mutations in shaping the earliest stages of carcinogenesis. This will provide mechanistic insights into cancer dependencies and vulnerabilities that could help guide the development of novel therapies. Her goal is to translate genetic markers of cancer risk into clinical action through the development of chemoprevention and early detection studies. As such she has ongoing clinical trials in chemoprevention. In her clinical work, she specializes in the management of individuals at high risk of hematologic malignancy based on genomic profile (both acquired and germline genetic variation).